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- Title
The Characterization of OXA-232 Carbapenemase-Producing ST437 Klebsiella pneumoniae in China.
- Authors
Weng, Xingbei; Shi, Qiucheng; Wang, Sheng; Shi, Yubo; Sun, Dinghe; Yu, Yunsong
- Abstract
Carbapenem-resistant Klebsiella pneumoniae (CRKP) was epidemic around the world and become a global threat to public health. The most important carbapenem-resistant mechanism is producing carbapenemases, especially Klebsiella pneumoniae carbapenemase (KPC), which is prevalent in the international clonal complex CC11. The high-risk multidrug-resistant CC11 is widespread worldwide, and KPC-producing and (New Delhi metallo) NDM-producing strains had been reported in this clonal complex before; moreover, cases with the CC11 strain faced more severe forms of drug resistance and treatment challenges than other clonal complexes. In this study, we identified an OXA-232-producing ST437 Klebsiella pneumoniae isolate in China, which belonged to CC11. The isolate was resistant to β-lactams, aminoglycosides, and fluoroquinolones but susceptible to fosfomycin, tigecycline, and colistin. The blaOXA-232 gene was located on a 6141 bp ColKP3-type nonconjugative plasmid, and the plasmid was transformed by chemical transformation successfully. This is the first report of OXA-232-producing ST437 K. pneumoniae in China, a new clone of high-risk multidrug-resistant CC11.
- Subjects
CHINA; NEW Delhi (India); KLEBSIELLA pneumoniae; KLEBSIELLA infections; CARBAPENEM-resistant bacteria; CHEMICAL amplification; DRUG resistance; CARBAPENEMASE
- Publication
Canadian Journal of Infectious Diseases & Medical Microbiology, 2020, p1
- ISSN
1712-9532
- Publication type
Article
- DOI
10.1155/2020/5626503