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- Title
Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP<sup>+</sup>/ MPTP Models of Parkinson's Disease In Vitro and In Vivo.
- Authors
Lo, Yi-Ching; Shih, Yu-Tzu; Tseng, Yu-Ting; Hsu, Hung-Te
- Abstract
San-Huang-Xie-Xin-Tang (SHXT), composed of Coptidis rhizoma, Scutellariae radix, and Rhei rhizoma, is a traditional Chinese medicine used for complementary and alternative therapy of cardiovascular and neurodegenerative diseases via its antiinflammatory and antioxidative effects. The aim of this study is to investigate the protective effects of SHXT in the 1-methyl-4- phenylpyridinium ( MPP+)/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP) models of Parkinson's disease. Rat primary mesencephalic neurons andmouse Parkinson diseasemodel were used in this study. Oxidative stress was induced by MPP+ in vitro and MPTP in vivo. In MPP+-treated mesencephalic neuron cultures, SHXT significantly increased the numbers of TH-positive neurons. SHXT reduced apoptotic signals (cytochrome and caspase) and apoptotic death. MPP+-induced gp91phox activation and ROS production were attenuated by SHXT. In addition, SHXT increased the levels of GSH and SOD in MPP+-treated neurons. In MPTP animal model, SHXT markedly increased TH-positive neurons in the substantia nigra pars compacta (SNpc) and improved motor activity of mice. In conclusion, the present results reveal the evidence that SHXT possesses beneficial protection against MPTP-induced neurotoxicity in this model of Parkinson's disease via its antioxidative and antiapoptotic effects. SHXT might be a potentially alternative and complementary medicine for neuroprotection.
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2012, Vol 2012, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2012/501032