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- Title
Comparison of different settings for yellow subthreshold laser treatment in diabetic macular edema.
- Authors
Chhablani, Jay; Alshareef, Rayan; Kim, David Ta; Narayanan, Raja; Goud, Abhilash; Mathai, Annie
- Abstract
<bold>Background: </bold>To assess the safety and efficacy of two subthreshold parameters (5 and 15% duty cycle (DC)) compared to standard ETDRS (early treatment of diabetic retinopathy study) continuous wave (CW) laser.<bold>Methods: </bold>In this prospective randomized study, 30 eyes from 20 patients with non-center involving macular edema were randomized into 3 different groups: 5% DC, 15% DC and CW navigated modified ETDRS laser treatment. Titration in subthreshold groups was performed with 30% of the threshold power, decided with microsecond pulses. CW laser was titrated to a barely visible burn. All patients underwent microperimetry, thickness measurements and visual acuity examinations at baseline, 6 weeks and 12 weeks post treatment.<bold>Results: </bold>At three months follow up, retinal sensitivity was significantly reduced in the CW group by - 2.2 dB whereas in both subthreshold groups, retinal sensitivity increased by 2.4 dB for 5% and 1.9 dB for 15% DC with no significant difference. Retinal volume (mm3) decreased in both subthreshold groups by 0.08 ± 0.3 and 0.12 ± 0.11 in 5 and 15% DC group respectively. Whereas the CW group showed volume increase of 0.55 ± 0.92 (p = 0.02 and 0.01 for 5 and 15% DC groups). Visual acuity remained stable in all 3 groups (- 0.7 letter in 5% DC; 2.11 letters in 15% DC and 0.88 in CW with no significant difference).<bold>Conclusion: </bold>Subthreshold microsecond laser was shown to be safe and effective with both 5 and 15% DC as compared to conventional photocoagulation with ETDRS parameters. The 15% DC setting trended to achieve better anatomical, visual and functional outcomes.<bold>Trial Registration: </bold>Retrospectively registered ( NCT03571659 , 06/26/2018).
- Subjects
RANDOMIZED controlled trials; CLINICAL trials; VISUAL acuity; PEOPLE with diabetes; VOLUMETRIC analysis
- Publication
BMC Ophthalmology, 2018, Vol 18, Issue 1, pN.PAG
- ISSN
1471-2415
- Publication type
journal article
- DOI
10.1186/s12886-018-0841-z