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- Title
Aberrant Resting-State Functional Connectivity Density in Patients with Hepatitis B Virus-Related Cirrhosis.
- Authors
Lv, Xiao-Fei; Wu, Hua-Wang; Tian, Li; Han, Lu-Jun; Li, Jing; Qiu, Ying-Wei; Jiang, Gui-Hua; Zhang, Xue-Lin; Zhang, Rong; Xie, Chuan-Miao
- Abstract
There is increasing evidence that cirrhosis may affect functional connectivity among various brain regions in patients prior to onset of overt hepatic encephalopathy (HE). However, most investigators have focused mainly on alterations in functional connectivity strengths, and the changes in functional connectivity density (FCD) are largely unknown. Here, we investigated alterations in resting-state FCD in patients with hepatitis B virus-related cirrhosis (HBV-RC) without overt HE. Totally, 31 patients with HBV-RC without overt HE and 30 age- and sex-matched healthy controls underwent resting-state functional MRI examinations. FCD mapping was employed to compute local and global FCD maps. Then, short-range and long-range FCD values were calculated and voxel-based comparisons were performed between the two groups. The HBV-RC group showed significant decreases in FCD, including decreased short-range FCDs in the bilateral middle cingulum gyrus/precuneus, the bilateral cuneus, and the left lingual gyrus/inferior occipital gyrus and decreased long-range FCD in the bilateral cuneus/precuneus. In addition, the decreased long-range FCD in the bilateral cuneus/precuneus in the HBV-RC group was related to performance on the psychometric hepatic encephalopathy score (PHES) test. These findings suggest aberrant functional connectivity density in cirrhotic patients prior to overt HE onset, which may provide better insight into understanding the pathophysiological mechanisms underlying the cirrhotic-related cognitive impairment.
- Subjects
ANALYSIS of covariance; BRAIN mapping; COGNITION disorders; STATISTICAL correlation; HEPATITIS B; LIMBIC system; CIRRHOSIS of the liver; LONGITUDINAL method; MAGNETIC resonance imaging; NEUROPSYCHOLOGICAL tests; OCCIPITAL lobe; PARIETAL lobe; PROBABILITY theory; RESEARCH funding; STATISTICS; T-test (Statistics); DATA analysis; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test; DISEASE complications
- Publication
BioMed Research International, 2016, Vol 2016, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2016/4168512