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- Title
A Novel Peptide Binding Prediction Approach for HLA-DR Molecule Based on Sequence and Structural Information.
- Authors
Li, Zhao; Zhao, Yilei; Pan, Gaofeng; Tang, Jijun; Guo, Fei
- Abstract
MHC molecule plays a key role in immunology, and the molecule binding reaction with peptide is an important prerequisite for T cell immunity induced. MHC II molecules do not have conserved residues, so they appear as open grooves. As a consequence, this will increase the difficulty in predicting MHC II molecules binding peptides. In this paper, we aim to propose a novel prediction method for MHC II molecules binding peptides. First, we calculate sequence similarity and structural similarity between different MHC II molecules. Then, we reorder pseudosequences according to descending similarity values and use a weight calculation formula to calculate new pocket profiles. Finally, we use three scoring functions to predict binding cores and evaluate the accuracy of prediction to judge performance of each scoring function. In the experiment, we set a parameter α in the weight formula. By changing α value, we can observe different performances of each scoring function. We compare our method with the best function to some popular prediction methods and ultimately find that our method outperforms them in identifying binding cores of HLA-DR molecules.
- Subjects
PEPTIDE analysis; ALLELES; ANTIGENS; BINDING sites; CELL receptors; HISTOCOMPATIBILITY; IMMUNITY; RESEARCH funding; T cells; HLA-B27 antigen; DATA analysis software; DESCRIPTIVE statistics; SEQUENCE analysis
- Publication
BioMed Research International, 2016, Vol 2016, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2016/3832176