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- Title
Effect of an Educational Program (PEGASE) on Cardiovascular Risk in Hypercholesterolaemic Patients.
- Authors
Eric Bruckert; Philippe Giral; François Paillard; Jean Ferrières; Jean-Louis Schlienger; Jean-François Renucci; Kamel Abdennbi; Isabelle Durack; Rita Chadarevian
- Abstract
Abstract Background Many studies have demonstrated a gap between guidelines for the prevention of cardiovascular disease (CVD) and their implementation in clinical practice. Aim The PEGASE education program has been devised with an aim to improve the management of patients at high risk of CVD. Methods In a multicentre study carried out from 2001–2004 in France, 96 participating physicians were randomized into a “trained” group, which included 398 “educated” patients, and a “non-trained” group, which included 242 “non-educated” patients. Educated patients received six hospital-based educational sessions, four collective and two individual. Framingham score, smoking, lipid levels, glycaemia, blood pressure, dietary intake and drug compliance, as well as quality of life, were evaluated at baseline (M0) and 6 months (M6). The primary endpoint of the study was the efficacy of the PEGASE program in reducing global CVD risk in high-risk patients. Results The Framingham score was calculated for 473 patients. The Framingham score improved significantly at M6 vs M0 in the educated group (13.0 ± 8.21 vs 13.6 ± 8.48, d = −0.658, p = 0.016), but not in the non-educated group (12.5 ± 8.19 vs 12.4 ± 7.81, d = +0.064, p = 0.836); the mean change between the two groups did not reach significance. Quality of life, LDL-c level and diet scores improved in the “educated” group only. Conclusions The PEGASE education program improved risk factors for CVD, although global assessment by Framingham score was not significantly different between groups. This program, aimed at meeting needs and expectations of patients and physicians, was easily implemented in all hospital centres.
- Subjects
PATIENTS; PERSONS; PATIENT education; PSYCHOLOGY of the sick
- Publication
Cardiovascular Drugs & Therapy, 2008, Vol 22, Issue 6, p495
- ISSN
0920-3206
- Publication type
Article