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Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors.
- Published in:
- Biopharmaceutics & Drug Disposition, 2011, v. 32, n. 6, p. 303, doi. 10.1002/bdd.760
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- Publication type:
- Article
Towards a Best Practice Approach in PBPK Modeling: Case Example of Developing a Unified Efavirenz Model Accounting for Induction of CYPs 3A4 and 2B6.
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- CPT: Pharmacometrics & Systems Pharmacology, 2016, v. 5, n. 7, p. 367, doi. 10.1002/psp4.12088
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- Publication type:
- Article
Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development.
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- CPT: Pharmacometrics & Systems Pharmacology, 2013, v. 2, n. 8, p. 1, doi. 10.1038/psp.2013.41
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- Publication type:
- Article
Evaluation of an In Silico PBPK Post-Bariatric Surgery Model through Simulating Oral Drug Bioavailability of Atorvastatin and Cyclosporine.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2013, v. 2, n. 6, p. 1, doi. 10.1038/psp.2013.23
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- Publication type:
- Article
A Mechanistic Framework for In Vitro-In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug-Drug Interaction Between Rosuvastatin and Cyclosporine.
- Published in:
- Clinical Pharmacokinetics, 2014, v. 53, n. 1, p. 73, doi. 10.1007/s40262-013-0097-y
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- Publication type:
- Article
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.
- Published in:
- 2011
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- Publication type:
- journal article