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- Title
INGs are potential drug targets for cancer.
- Authors
Zhang, Runyun; Jin, Jianhua; Shi, Juanjuan; Hou, Yongzhong
- Abstract
Purpose: The inhibitor of growth (ING) family consists of ING1, ING2, ING3, ING4 and ING5, which function as the type II tumor suppressors. INGs regulate cell proliferation, senescence, apoptosis, differentiation, angiogenesis, DNA repair, metastasis, and invasion by multiple pathways. In addition, INGs increase cancer cell sensitivity for chemotherapy and radiotherapy, while clinical observations show that INGs are frequently lost in some types of cancers. The aim of the study was to summarize the recent progress regarding INGs regulating tumor progression. Methods: The literatures of INGs regulating tumor progression were searched and assayed. Results: The regulating signaling pathways of ING1, ING2, ING3 or ING4 on tumor progression were shown. The mechanisms of INGs on tumor suppression were also assayed. Conclusions: This review better summarized the signaling mechanism of INGs on tumor suppression, which provides a candidate therapy strategy for cancers.
- Subjects
CANCER treatment; DRUG target; CELL proliferation; TUMOR suppressor genes; APOPTOSIS
- Publication
Journal of Cancer Research & Clinical Oncology, 2017, Vol 143, Issue 2, p189
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-016-2219-z