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- Title
Perfusion CT in patients with advanced bronchial carcinomas: a novel chance for characterization and treatment monitoring?
- Authors
Kiessling, F.; Boese, J.; Corvinus, C.; Ederle, J. R.; Zuna, I.; Schoenberg, S. O.; Brix, G.; Schmähl, A.; Tuengerthal, S.; Herth, F.; Kauczor, H. U.; Essig, M.; Schmähl, A
- Abstract
Advanced bronchial carcinomas by means of perfusion and peak enhancement using dynamic contrast-enhanced multislice CT are characterized. Twenty-four patients with advanced bronchial carcinoma were examined. During breathhold, after injection of a contrast-medium (CM), 25 scans were performed (1 scan/s) at a fixed table position. Density-time curves were evaluated from regions of interest of the whole tumor and high- and low-enhancing tumor areas. Perfusion and peak enhancement were calculated using the maximum-slope method of Miles and compared with size, localization (central or peripheral) and histology. Perfusion of large tumors (> 50 cm3) averaged over both the whole tumor (P = 0.001) and the highest enhancing area (P = 0.003) was significantly lower than that of smaller ones. Independent of size, central carcinomas had a significantly (P = 0.04) lower perfusion (mean 27.9 ml/min/100 g) than peripheral ones (mean 66.5 ml/min/100 g). In contrast, peak enhancement of central and peripheral carcinomas was not significantly different. Between non-small-cell lung cancers and small-cell lung cancers, no significant differences were observed in both parameters. In seven tumors, density increase after CM administration started earlier than in the aorta, indicating considerable blood supply from pulmonary vessels. Tumor perfusion was dependent on tumor size and localization, but not on histology. Furthermore, perfusion CT disclosed blood supply from both pulmonary and/or bronchial vessels in some tumors.
- Subjects
CHEST tumors; ONCOLOGY; ARTERIES; BLOOD circulation; TISSUES; CYSTS (Pathology)
- Publication
European Radiology, 2004, Vol 14, Issue 7, p1226
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-004-2288-2