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- Title
Synthesis, Characterizations, and 9.4 Tesla T 2 MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide Nanoparticles.
- Authors
Marasini, Shanti; Yue, Huan; Ho, Son Long; Park, Ji Ae; Kim, Soyeon; Jung, Ki-Hye; Cha, Hyunsil; Liu, Shuwen; Tegafaw, Tirusew; Ahmad, Mohammad Yaseen; Ghazanfari, Adibehalsadat; Chae, Kwon-Seok; Chang, Yongmin; Lee, Gang Ho; Marquina, Clara
- Abstract
Polyacrylic acid (PAA)-coated lanthanide oxide (Ln2O3) nanoparticles (NPs) (Ln = Tb and Ho) with high colloidal stability and good biocompatibility were synthesized, characterized, and investigated as a new class of negative (T2) magnetic resonance imaging (MRI) contrast agents at high MR fields. Their r2 values were appreciable at a 3.0 T MR field and higher at a 9.4 T MR field, whereas their r1 values were negligible at all MR fields, indicating their exclusive induction of T2 relaxations with negligible induction of T1 relaxations. Their effectiveness as T2 MRI contrast agents at high MR fields was confirmed from strong negative contrast enhancements in in vivo T2 MR images at a 9.4 T MR field after intravenous administration into mice tails.
- Subjects
TERBIUM; MAGNETIC resonance imaging; RARE earth oxides; HOLMIUM; POLYACRYLIC acid; COLLOIDAL stability
- Publication
Nanomaterials (2079-4991), 2021, Vol 11, Issue 5, p1355
- ISSN
2079-4991
- Publication type
Article
- DOI
10.3390/nano11051355