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- Title
Mortality in COPD: Comparison of Different Predictors in Patients Seeking a Pulmonary Rehabilitation Program.
- Authors
da Silva, Thamyres Spositon; Rodrigues, Antenor; Fonseca Micheleti, Juliana; Aparecida Hernandes, Nidia; Pitta, Fabio; Couto Furlanetto, Karina
- Abstract
It is clinically relevant to identify isolated factors or multidimensional predictors of mortality in patients with Chronic Obstructive Pulmonary Disease (COPD). To compare different factors in the identification of patients classified as high risk of death and to identify the prognostic value of isolated factors against the BODE index. Patients were evaluated considering the factors associated with mortality: pulmonary function with forced expiratory volume (FEV1); body mass index (BMI); body mass index (LMWI); Incremental Shuttle Walk Test (ISWT) with estimation of maximal oxygen consumption (VO2max); six-minute walk test (6MWT); Medical Research Council scale; BODE index and sedentary time. Cut-off points previously associated with risk of death were used to calculate the proportion of patients at high risk of death. ROC curve analysis was used to test the prognostic value of each variable against the BODE index. A total of 162 patients (86 men, age 67 ± 8 years) were included. The proportions of patients classified as high risk ranged from 12.6 to 76.5% according to all eight factors analyzed (P <0.05 vs all). The area under the curve (AUC) of each factor analyzed against the BODE index indicated insufficient discriminative capacity (0.26 < AUC < 0.44). Conclusion: There is an expressive variability of patients classified as "high risk" according to each predictor factor. Moreover, the prognostic evaluation of the patient using the BODE index cannot be replaced by the assessment of a single predictive factor.
- Subjects
MORTALITY risk factors; EXERCISE; HELP-seeking behavior; LUNG diseases; OBSTRUCTIVE lung diseases; MEDICAL rehabilitation; PULMONARY function tests; RISK assessment; BODY mass index; OXYGEN consumption; VITAL capacity (Respiration); RECEIVER operating characteristic curves; SEDENTARY lifestyles
- Publication
Journal of Health Sciences (2447-8938), 2019, Vol 21, Issue 4, p390
- ISSN
2447-8938
- Publication type
Article
- DOI
10.17921/2447-8938.2019v21n4p390-6