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- Title
Synthesis of Transition Metal Complexes of Isoniazid Derivatives and Urease Inhibition Activity Detection.
- Authors
Yi-Heng Zhang; Ze-Yu Fang; Juan Sun; Yuan-Feng Wu
- Abstract
It have been reported that the transition metal complex of Schiff base ligands have the ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes [Cd2(L)2·(H2O)] (1), [Pb(L)·, [Pbe2) were synthesized based on chelating hydrazone ligand N'-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested by single crystal X-ray diffraction and determined by structure and tested for urease resistance in vitro. The complex 2 exhibited better the activities of inhibiting than the positive control acetohydroxamic acid with an IC50 =2.5 μM, while the complex 1 showed weak activity, and complex 2 acted as an effective urease inhibitor.
- Subjects
UREASE; METAL complexes; SINGLE crystal testing; TRANSITION metal complexes; ISONIAZID; SCHIFF bases
- Publication
Indian Journal of Pharmaceutical Education & Research, 2022, Vol 56, Issue 2, p573
- ISSN
0019-5464
- Publication type
Article
- DOI
10.5530/ijper.56.2.80