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- Title
Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features.
- Authors
Ronchi, Andrea; Cozzolino, Immacolata; Montella, Marco; Panarese, Iacopo; Zito Marino, Federica; Rossetti, Sabrina; Chieffi, Paolo; Accardo, Marina; Facchini, Gaetano; Franco, Renato
- Abstract
Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis from occult gonadal neoplasms. The actual observations suggest that EGGCTs represent a unique entity, so their biology and behavior are substantially different from gonadal counterparts. The diagnosis of EGGCTs is often challenging, and differential diagnosis is particularly wide. Nevertheless, a correct diagnosis is essential for the correct management of the patient. We summarize the state of art about EGGCTs, with particular emphasis on diagnosis and prognosis.
- Subjects
GERM cell tumors; PATHOLOGY; GONADAL diseases; BIOLOGY; TUMORS; DIFFERENTIAL diagnosis
- Publication
Cancer Medicine, 2019, Vol 8, Issue 16, p6832
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.2195