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- Title
Migraine, weight gain and the risk of becoming overweight and obese: A prospective cohort study.
- Authors
Winter, Anke C; Wang, Lu; Buring, Julie E; Sesso, Howard D; Kurth, Tobias
- Abstract
Background: Some cross-sectional studies have suggested an association between migraine and increased body weight. However, prospective data on +e association are lacking. Me+ods: We conducted a prospective cohort study among 19,162 participants in +e Women's Heal+ Study who had a body mass index (BMI) of 18.5- <25 kg/m2 at baseline. Migraine was self-reported by standardized questionnaires. Main outcome measures were incident overweight (BMI>;25 kg/m2), incident obesity (BMI>30 kg/m2) and mean weight change. Age- and multivariable-adjusted hazard ratios (HRs) were calculated for +e association between migraine and incident overweight and obesity. Differences in weight change were evaluated by analysis of covariance (ANCOVA).Results: A total of 3,483 (18.2%) women reported any migraine history. After 12.9 years of follow-up, 7916 incident overweight and 730 incident obesity cases occurred. Migraineurs had multivariable-adjusted HRs (95% confidence interval) of 1.11 (1.05-1.17) for becoming overweight and 1.00 (0.83-1.19) for becoming obese. +ese associations remained stable after censoring for chronic diseases and were similar according to migraine aura status. Multivariable-adjusted mean weight change from baseline to +e end of study was +4.7 kg for migraineurs and +4.4 kg for women wi+out migraine (p=0.02). Conclusion: Results of +is large prospective study of middle-aged women do not indicate a consistent association between migraine and incident overweight, obesity or relevant weight gain.
- Subjects
MIGRAINE; HEADACHE; WEIGHT gain; BODY weight; OBESITY
- Publication
Cephalalgia, 2012, Vol 32, Issue 13, p963
- ISSN
0333-1024
- Publication type
Article
- DOI
10.1177/0333102412455708