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- Title
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.
- Authors
Maglione, Marta; Kochlamazashvili, Gaga; Eisenberg, Tobias; Rácz, Bence; Michael, Eva; Toppe, David; Stumpf, Alexander; Wirth, Alexander; Zeug, André; Müller, Franziska E.; Moreno-Velasquez, Laura; Sammons, Rosanna P.; Hofer, Sebastian J.; Madeo, Frank; Maritzen, Tanja; Maier, Nikolaus; Ponimaskin, Evgeni; Schmitz, Dietmar; Haucke, Volker; Sigrist, Stephan J.
- Abstract
Aging is associated with functional alterations of synapses thought to contribute to age-dependent memory impairment (AMI). While therapeutic avenues to protect from AMI are largely elusive, supplementation of spermidine, a polyamine normally declining with age, has been shown to restore defective proteostasis and to protect from AMI in Drosophila. Here we demonstrate that dietary spermidine protects from age-related synaptic alterations at hippocampal mossy fiber (MF)-CA3 synapses and prevents the aging-induced loss of neuronal mitochondria. Dietary spermidine rescued age-dependent decreases in synaptic vesicle density and largely restored defective presynaptic MF-CA3 long-term potentiation (LTP) at MF-CA3 synapses (MF-CA3) in aged animals. In contrast, spermidine failed to protect CA3-CA1 hippocampal synapses characterized by postsynaptic LTP from age-related changes in function and morphology. Our data demonstrate that dietary spermidine attenuates age-associated deterioration of MF-CA3 synaptic transmission and plasticity. These findings provide a physiological and molecular basis for the future therapeutic usage of spermidine.
- Subjects
SPERMIDINE; HIPPOCAMPAL innervation; POLYAMINES; MITOCHONDRIA; NEURAL transmission
- Publication
Scientific Reports, 2019, Vol 9, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-019-56133-3