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- Title
Clinicopathological and immunohistochemical analysis of spindle-cell carcinoid tumour of the lung.
- Authors
Tsuta, Koji; Kalhor, Neda; Wistuba, Ignacio I; Moran, Cesar A
- Abstract
Tsuta K, Kalhor N, Wistuba I I & Moran C A (2011) Histopathology 59, 526-536 Clinicopathological and immunohistochemical analysis of spindle-cell carcinoid tumour of the lung Aims: To analyse the clinicopathological features and immunohistchemical profile of spindle-cell carcinoid tumours (SCCT) of the lung. Methods and results: Using a cut-off value of ≥50% spindle cells for defining SCCT, 13 were indentified among 80 consecutively resected carcinoid cases. SCCTs are asymptomatic and are peripherally located, well-demarcated tumours. Tumour cells were composed of elongated spindle cells, with scant to moderate amounts of cytoplasm and uniform nuclei with fine granular chromatin. Immunohistochemical analysis revealed that all 13 cases were positive for three neuroendocrine markers (chromogranin A, synaptophysin and CD56). Four tumours (30.7%) were positive for broad-spectrum cytokeratin (CK) and nine tumours (69.2%) were positive for thyroid transcription factor 1. All epithelial components were negative for vimentin, but 12 tumours (92.3%) were positive for stellate-shaped cells (so-called sustentacular cells). Conclusions: SCCTs are clinically asymptomatic, peripherally located, well-demarcated tumours, and patients with SCCTs have a favourable outcome. The immunoreactivity pattern of SCCT (low reactivity of broad-spectrum CK and reactivity for vimentin in intratumoral sustentacular cells) might result in a misdiagnosis of SCCT as mesenchymal tumour; therefore, pathologists need to be familiar with this pattern.
- Subjects
CARCINOID; LUNG cancer; CANCER cells; CYTOPLASM; CHROMATIN; IMMUNOHISTOCHEMISTRY; TRANSCRIPTION factors
- Publication
Histopathology, 2011, Vol 59, Issue 3, p526
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/j.1365-2559.2011.03966.x