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- Title
A patient with bullous pemphigoid with mucosal involvement serologically positive for anti‐BP230 autoantibodies only.
- Authors
Taki, T.; Takeichi, T.; Kono, M.; Sugiura, K.; Sugimura, Y.; Ishii, N.; Hashimoto, T.; Akiyama, M.
- Abstract
Immunoblotting (IB) analysis using normal human epidermal extract as the substrate showed that the patient's IgG autoantibodies reacted with BP230, but not with BP180 (Fig. f). Enzyme-linked immunosorbent assays revealed that IgG autoantibodies in the patient's serum reacted with BP230 (index: 87-28; cut-off: < 9), but not with the NC16A domain of BP180 (index: < 3; cut-off: < 9) (MBL, Nagoya, Japan). Patients with BP have circulating IgG anti-BMZ autoantibodies that react primarily with BP180 and/or BP230.
- Subjects
BULLOUS pemphigoid; MEMBRANE proteins; RECOMBINANT proteins
- Publication
British Journal of Dermatology, 2020, Vol 182, Issue 1, p221
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/bjd.18343