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- Title
Is it possible to predict treatment response to a proton pump inhibitor in functional dyspepsia?
- Authors
Bolling‐Sternevald, E.; Lauritsen, K.; Talley, N. J.; Junghard, O.; Glise, H.
- Abstract
Summary Background: The efficacy of proton pump inhibitors in functional dyspepsia is modest and the prognostic factors are almost unknown. Methods: Data were pooled on patients (n = 826) with a diagnosis of functional dyspepsia from two placebo-controlled trials who were treated with omeprazole, 10 or 20 mg once daily, for 4 weeks. Self-administered questionnaires for the assessment of symptoms and health-related quality of life were completed before entry, and epigastric pain/discomfort was recorded on diary cards. Treatment success was defined as the complete absence of epigastric pain/discomfort on each of the last 3 days of week 4. Prognostic factors were identified by multiple logistic regression analysis. Results: The most discriminating predictor of treatment success (P < 0.0001) was the number of days with epigastric pain/discomfort during the first week of treatment. Fewer days with symptoms during the first week led to higher response rates at 4 weeks. In addition, age > 40 years, bothersome heartburn, low scores for bloating, epigastric pain and diarrhoea, history of symptoms for < 3 months and low impairment of vitality at baseline were identified as positive predictors of outcome. Conclusions: Early response to treatment with a proton pump inhibitor, during the first week, seems to predict the outcome after 4 weeks in patients with functional dyspepsia.
- Subjects
PROTON pump inhibitors; INDIGESTION
- Publication
Alimentary Pharmacology & Therapeutics, 2003, Vol 18, Issue 1, p117
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1046/j.1365-2036.2003.01651.x