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- Title
Persistent reduction in brain serotonin<sub>1A</sub> receptor binding in recovered depressed men measured by positron emission tomography with [<sup>11</sup>C]WAY-100635.
- Authors
Bhagwagar, Z.; Rabiner, E. A.; Sargent, P. A.; Grasby, P. M.; Cowen, P. J.
- Abstract
Positron emission tomography (PET) studies with the selective 5-HT1A receptor ligand, [11C]WAY-100635, have indicated that the binding potential (BP) of brain 5-HT1A receptors is lowered in unmedicated subjects with acute major depression. However, it is unclear if these changes persist after recovery from depression. To resolve this issue, we used [11C]WAY-100635 in conjunction with PET imaging to compare 5-HT1A BP in 18 healthy controls and 14 male subjects with recurrent major depression who were clinically recovered and free of antidepressant medication. BP values, derived from a reference tissue model, were analysed by region of interest and statistical parametric mapping. Both analyses showed a widespread and substantial (17%) decrease in 5-HT1A receptor BP in cortical areas in the recovered depressed subjects. In contrast, 5-HT1A BP in the raphe nuclei did not distinguish depressed subjects from controls. Our results suggest a persistent dysfunction in cortical 5-HT1A BP as measured by [11C]WAY-100635 in recovered depressed men. Lowered 5-HT1A receptor binding availability could represent a trait abnormality that confers vulnerability to recurrent major depression.Molecular Psychiatry (2004) 9, 386-392. doi:10.1038/sj.mp.4001401
- Subjects
POSITRON emission tomography; MENTAL depression; AFFECTIVE disorders; PATHOLOGICAL psychology; PSYCHOLOGY; HUMAN biology
- Publication
Molecular Psychiatry, 2004, Vol 9, Issue 4, p386
- ISSN
1359-4184
- Publication type
Article
- DOI
10.1038/sj.mp.4001401