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- Title
DC-induced CD8.
- Authors
Han, Wanda G. H.; Schuurhuis, Danita H.; Fu, Nathalie; Camps, Marcel; van Duivenvoorde, Leonie M.; Louis-Plence, Pascale; Franken, Kees L. M. C.; Huizinga, Tom W. J.; Melief, Cornelis J. M.; Toes, René E. M.; Ossendorp, Ferry
- Abstract
CD4 T cells are important for CD8 T-cell priming by providing cognate signals for DC maturation. We analyzed the capacity of CD4 T cells to influence CD8 T-cell responses induced by activated DC. Surprisingly, mice depleted for CD4 cells were able to generate stronger antigen-specific CD8 T-cell responses after DC vaccination than non-depleted mice. The same observation was made when mice were vaccinated with MHC class II DC, indicating the presence of a MHC class II-dependent CD4 T-cell population inhibiting CD8 T-cell responses. Recently we described the expansion of DX5CD4 T cells, a T-cell population displaying immune regulatory properties, upon vaccination with DC. Intriguingly, we now observe an inverse correlation between CD8 T-cell induction and expansion of DX5CD4 T cells as the latter cells did not expand after vaccination with MHC class II DC. In vitro, DX5CD4 T cells were able to limit proliferation, modulate cytokine production and induce Foxp3 expression in OVA-specific CD8 T cells. Together, our data show an inhibitory role of CD4 T cells on the induction of CD8 T-cell responses by activated DC and indicate the involvement of DX5CD4, but not CD4CD25, T cells in this process.
- Publication
European Journal of Immunology, 2009, Vol 39, Issue 7, p1765
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200838842