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Neonatal Cytomegalovirus Palatal Ulceration and Bocavirus Pneumonitis Associated With a Defect of Lymphocyte Cytotoxicity Caused by Mutations in UNC13D.
Published in:
Journal of the Pediatric Infectious Diseases Society, 2019, v. 8, n. 1, p. 73, doi. 10.1093/jpids/pix112
By:
- Gray, Paul Edgar;
- Shadur, Bella;
- Russell, Susan;
- Mitchell, Richard;
- Gallagher, Kerri;
- Thia, Kevin;
- Palasanthiran, Pamela;
- Voskoboinik, Ilia
Publication type:
Article
The MACPF/CDC family of pore-forming toxins.
Published in:
Cellular Microbiology, 2008, v. 10, n. 9, p. 1765, doi. 10.1111/j.1462-5822.2008.01191.x
By:
- Rosado, Carlos J.;
- Kondos, Stephanie;
- Bull, Tara E.;
- Kuiper, Michael J.;
- Law, Ruby H. P.;
- Buckle, Ashley M.;
- Voskoboinik, Ilia;
- Bird, Phillip I.;
- Trapani, Joseph A.;
- Whisstock, James C.;
- Dunstone, Michelle A.
Publication type:
Article
Deciphering the syntax of cytotoxic lymphocyte degranulation.
Published in:
European Journal of Immunology, 2013, v. 43, n. 1, p. 46, doi. 10.1002/eji.201243221
By:
- Lopez, Jamie A.;
- Voskoboinik, Ilia
Publication type:
Article
Defining the interaction of perforin with calcium and the phospholipid membrane.
Published in:
Biochemical Journal, 2013, v. 456, n. 3, p. 323, doi. 10.1042/BJ20130999
By:
- TRAORE, Daouda A. K.;
- BRENNAN, Amelia J.;
- LAW, Ruby H. P.;
- DOGOVSKI, Con;
- PERUGINI, Matthew A.;
- LUKOYANOVA, Natalya;
- LEUNG, Eleanor W. W.;
- NORTON, Raymond S.;
- LOPEZ, Jamie A.;
- BROWNE, Kylie A.;
- YAGITA, Hideo;
- LLOYD, Gordon J.;
- CICCONE, Annette;
- VERSCHOOR, Sandra;
- TRAPANI, Joseph A.;
- WHISSTOCK, James C.;
- VOSKOBOINIK, Ilia
Publication type:
Article
Safety Profile of a Multi-Antigenic DNA Vaccine Against Hepatitis C Virus.
Published in:
Vaccines, 2020, v. 8, n. 1, p. 53, doi. 10.3390/vaccines8010053
By:
- Gummow, Jason;
- Masavuli, Makutiro G.;
- Mekonnen, Zelalem A.;
- Li, Yanrui;
- Wijesundara, Danushka K.;
- Shrestha, Ashish C.;
- Voskoboinik, Ilia;
- Gowans, Eric J.;
- Grubor-Bauk, Branka
Publication type:
Article
Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24577-9
By:
- Fareh, Mohamed;
- Zhao, Wei;
- Hu, Wenxin;
- Casan, Joshua M. L.;
- Kumar, Amit;
- Symons, Jori;
- Zerbato, Jennifer M.;
- Fong, Danielle;
- Voskoboinik, Ilia;
- Ekert, Paul G.;
- Rudraraju, Rajeev;
- Purcell, Damian F. J.;
- Lewin, Sharon R.;
- Trapani, Joseph A.
Publication type:
Article
Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis.
Published in:
British Journal of Haematology, 2020, v. 190, n. 3, p. 458, doi. 10.1111/bjh.16660
By:
- Jang, Helena S.;
- Flinsenberg, Thijs W. H.;
- Lacaze, Paul;
- Thia, Kevin Y. T.;
- Noori, Tahereh;
- Fernando, Suran L.;
- Kerridge, Ian;
- Riaz, Moeen;
- McNeil, John J.;
- Blombery, Piers A.;
- Trapani, Joseph A.;
- Voskoboinik, Ilia
Publication type:
Article
Bi-allelic Mutations in stXBp2 Reveal a Complementary Role for stXBp1 in Cytotoxic Lymphocyte Killing.
Published in:
Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00529
By:
- Lopez, Jamie A.;
- Noori, Tahereh;
- Minson, Adrian;
- Li Jovanoska, Lu;
- Thia, Kevin;
- Hildebrand, Michael S.;
- Akhlaghi, Hedieh;
- Darcy, Phillip K.;
- Kershaw, Michael H.;
- Brown, Natasha J.;
- Grigg, Andrew;
- Trapani, Joseph A.;
- Voskoboinik, Ilia
Publication type:
Article
Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation.
Published in:
EMBO Reports, 2017, v. 18, n. 10, p. 1775, doi. 10.15252/embr.201744351
By:
- House, Imran G;
- House, Colin M;
- Brennan, Amelia J;
- Gilan, Omer;
- Dawson, Mark A;
- Whisstock, James C;
- Law, Ruby HP;
- Trapani, Joseph A;
- Voskoboinik, Ilia
Publication type:
Article
Lipid order and charge protect killer T cells from accidental death.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-13385-x
By:
- Rudd-Schmidt, Jesse A.;
- Hodel, Adrian W.;
- Noori, Tahereh;
- Lopez, Jamie A.;
- Cho, Hyun-Jung;
- Verschoor, Sandra;
- Ciccone, Annette;
- Trapani, Joseph A.;
- Hoogenboom, Bart W.;
- Voskoboinik, Ilia
Publication type:
Article
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12279-2
By:
- Pang, Siew Siew;
- Bayly-Jones, Charles;
- Radjainia, Mazdak;
- Spicer, Bradley A.;
- Law, Ruby H. P.;
- Hodel, Adrian W.;
- Parsons, Edward S.;
- Ekkel, Susan M.;
- Conroy, Paul J.;
- Ramm, Georg;
- Venugopal, Hariprasad;
- Bird, Phillip I.;
- Hoogenboom, Bart W.;
- Voskoboinik, Ilia;
- Gambin, Yann;
- Sierecki, Emma;
- Dunstone, Michelle A.;
- Whisstock, James C.
Publication type:
Article
Words of Advice: choosing the right lab for your post‐doctoral fellowship.
Published in:
FEBS Journal, 2021, v. 288, n. 6, p. 1734, doi. 10.1111/febs.15565
By:
- Trapani, Joseph A.;
- Voskoboinik, Ilia
Publication type:
Article
The structural basis for membrane binding and pore formation by lymphocyte perforin.
Published in:
Nature, 2010, v. 468, n. 7322, p. 447, doi. 10.1038/nature09518
By:
- Law, Ruby H. P.;
- Lukoyanova, Natalya;
- Voskoboinik, Ilia;
- Caradoc-Davies, Tom T.;
- Baran, Katherine;
- Dunstone, Michelle A.;
- D'Angelo, Michael E.;
- Orlova, Elena V.;
- Coulibaly, Fasséli;
- Verschoor, Sandra;
- Browne, Kylie A.;
- Ciccone, Annette;
- Kuiper, Michael J.;
- Bird, Phillip I.;
- Trapani, Joseph A.;
- Saibil, Helen R.;
- Whisstock, James C.
Publication type:
Article
Perforin and granzymes: function, dysfunction and human pathology.
Published in:
Nature Reviews Immunology, 2015, v. 15, n. 6, p. 388, doi. 10.1038/nri3839
By:
- Voskoboinik, Ilia;
- Whisstock, James C.;
- Trapani, Joseph A.
Publication type:
Article
Perforin-mediated target-cell death and immune homeostasis.
Published in:
Nature Reviews Immunology, 2006, v. 6, n. 12, p. 940, doi. 10.1038/nri1983
By:
- Voskoboinik, Ilia;
- Smyth, Mark J.;
- Trapani, Joseph A.
Publication type:
Article
Perforin: structure, function, and role in human immunopathology.
Published in:
Immunological Reviews, 2010, v. 235, n. 1, p. 35, doi. 10.1111/j.0105-2896.2010.00896.x
By:
- Voskoboinik, Ilia;
- Dunstone, Michelle A.;
- Baran, Katherine;
- Whisstock, James C.;
- Trapani, Joseph A.
Publication type:
Article
Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.
Published in:
FEBS Journal, 2016, v. 283, n. 5, p. 947, doi. 10.1111/febs.13649
By:
- Sutton, Vivien R.;
- Brennan, Amelia J.;
- Ellis, Sarah;
- Danne, Jill;
- Thia, Kevin;
- Jenkins, Misty R.;
- Voskoboinik, Ilia;
- Pejler, Gunnar;
- Johnstone, Ricky W.;
- Andrews, Daniel M.;
- Trapani, Joseph A.
Publication type:
Article
Tumor immune evasion arises through loss of TNF sensitivity.
Published in:
Science Immunology, 2018, v. 3, n. 23, p. 1, doi. 10.1126/sciimmunol.aar3451
By:
- Kearney, Conor J.;
- Vervoort, Stephin J.;
- Hogg, Simon J.;
- Ramsbottom, Kelly M.;
- Freeman, Andrew J.;
- Lalaoui, Najoua;
- Pijpers, Lizzy;
- Michie, Jessica;
- Brown, Kristin K.;
- Knight, Deborah A.;
- Sutton, Vivien;
- Beavis, Paul A.;
- Voskoboinik, Ilia;
- Darcy, Phil K.;
- Silke, John;
- Trapani, Joseph A.;
- Johnstone, Ricky W.;
- Oliaro, Jane
Publication type:
Article
Filaggrin-Associated Atopic Skin, Eye, Airways, and Gut Disease, Modifying the Presentation of X-Linked Reticular Pigmentary Disorder (XLPDR)
Published in:
Journal of Clinical Immunology, 2024, v. 44, n. 1, p. 1, doi. 10.1007/s10875-023-01637-x
By:
- Li, Margaret W. Y.;
- Burnett, Leslie;
- Dai, Pei;
- Avery, Danielle T.;
- Noori, Tahereh;
- Voskoboinik, Ilia;
- Shah, Parth R.;
- Tatian, Artiene;
- Tangye, Stuart G.;
- Gray, Paul E.;
- Ma, Cindy S.
Publication type:
Article
Late-onset Non-HLH presentations of Growth arrest, Inflammatory arachnoiditis, and severe Infectious Mononucleosis, in siblings with Hypomorphic Defects in UNC13D.
Published in:
Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.00944
By:
- Gray, Paul Edgar;
- Shadur, Bella;
- Russell, Susan;
- Mitchell, Richard;
- Buckley, Michael;
- Gallagher, Kerri;
- Andrews, Ian;
- Thia, Kevin;
- Trapani, Joseph A.;
- Kirk, Edwin Philip;
- Voskoboinik, Ilia
Publication type:
Article
Early hematopoietic cell transplantation for familial hemophagocytic lymphohistiocytosis in a regional treatment network in Japan.
Published in:
International Journal of Hematology, 2024, v. 119, n. 5, p. 592, doi. 10.1007/s12185-024-03721-3
By:
- Ishimura, Masataka;
- Eguchi, Katsuhide;
- Sonoda, Motoshi;
- Tanaka, Tamami;
- Shiraishi, Akira;
- Sakai, Yasunari;
- Yasumi, Takahiro;
- Miyamoto, Takayuki;
- Voskoboinik, Ilia;
- Hashimoto, Kunio;
- Matsumoto, Shirou;
- Ozono, Shuichi;
- Moritake, Hiroshi;
- Takada, Hidetoshi;
- Ohga, Shouichi
Publication type:
Article
Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin.
Published in:
PLoS Biology, 2015, v. 13, n. 2, p. 1, doi. 10.1371/journal.pbio.1002049
By:
- Lukoyanova, Natalya;
- Kondos, Stephanie C.;
- Farabella, Irene;
- Law, Ruby H. P.;
- Reboul, Cyril F.;
- Caradoc-Davies, Tom T.;
- Spicer, Bradley A.;
- Kleifeld, Oded;
- Traore, Daouda A. K.;
- Ekkel, Susan M.;
- Voskoboinik, Ilia;
- Trapani, Joseph A.;
- Hatfaludi, Tamas;
- Oliver, Katherine;
- Hotze, Eileen M.;
- Tweten, Rodney K.;
- Whisstock, James C.;
- Topf, Maya;
- Saibil, Helen R.;
- Dunstone, Michelle A.
Publication type:
Article
Dilemmas in the diagnosis and pathogenesis of atypical late‐onset familial haemophagocytic lymphohistiocytosis.
Published in:
Clinical & Translational Immunology, 2021, v. 10, n. 7, p. 1, doi. 10.1002/cti2.1320
By:
- Minson, Adrian;
- Voskoboinik, Ilia;
- Grigg, Andrew
Publication type:
Article
Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals.
Published in:
Immunology & Cell Biology, 2015, v. 93, n. 6, p. 575, doi. 10.1038/icb.2015.1
By:
- House, Imran G;
- Thia, Kevin;
- Brennan, Amelia J;
- Tothill, Richard;
- Dobrovic, Alexander;
- Yeh, Wei Z;
- Saffery, Richard;
- Chatterton, Zac;
- Trapani, Joseph A;
- Voskoboinik, Ilia
Publication type:
Article
Addressing the mysteries of perforin function.
Published in:
Immunology & Cell Biology, 2006, v. 84, n. 1, p. 66, doi. 10.1111/j.1440-1711.2005.01409.x
By:
- VOSKOBOINIK, ILIA;
- TRAPANI, JOSEPH A.
Publication type:
Article
Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells.
Published in:
Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1396710
By:
- Sutton, Vivien R.;
- Watt, Sally V.;
- Akhlaghi, Hedieh;
- Cipolla, David C.;
- Kuan-Ju Chen;
- LaSala, Daniel;
- McDonald, Patrick P.;
- Beavis, Paul A.;
- Munoz, Isabelle;
- Hodel, Adrian W.;
- Noori, Tahereh;
- Voskoboinik, Ilia;
- Trapani, Joseph A.
Publication type:
Article
Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function.
Published in:
Frontiers in Immunology, 2013, v. 4, p. 1, doi. 10.3389/fimmu.2013.00441
By:
- Trapani, Joseph A.;
- Voskoboinik, Ilia
Publication type:
Article

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