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- Title
Lkb1 suppresses amino acid-driven gluconeogenesis in the liver.
- Authors
Just, Pierre-Alexandre; Charawi, Sara; Denis, Raphaël G. P.; Savall, Mathilde; Traore, Massiré; Foretz, Marc; Bastu, Sultan; Magassa, Salimata; Senni, Nadia; Sohier, Pierre; Wursmer, Maud; Vasseur-Cognet, Mireille; Schmitt, Alain; Le Gall, Morgane; Leduc, Marjorie; Guillonneau, François; De Bandt, Jean-Pascal; Mayeux, Patrick; Romagnolo, Béatrice; Luquet, Serge
- Abstract
Excessive glucose production by the liver is a key factor in the hyperglycemia observed in type 2 diabetes mellitus (T2DM). Here, we highlight a novel role of liver kinase B1 (Lkb1) in this regulation. We show that mice with a hepatocyte-specific deletion of Lkb1 have higher levels of hepatic amino acid catabolism, driving gluconeogenesis. This effect is observed during both fasting and the postprandial period, identifying Lkb1 as a critical suppressor of postprandial hepatic gluconeogenesis. Hepatic Lkb1 deletion is associated with major changes in whole-body metabolism, leading to a lower lean body mass and, in the longer term, sarcopenia and cachexia, as a consequence of the diversion of amino acids to liver metabolism at the expense of muscle. Using genetic, proteomic and pharmacological approaches, we identify the aminotransferases and specifically Agxt as effectors of the suppressor function of Lkb1 in amino acid-driven gluconeogenesis. Excessive glucose production by the liver contributes to poor blood glucose control in type 2 diabetes. Here the authors report that the liver kinase B1 (Lkb1) suppresses amino acid driven postprandial glucose production in the liver through the aminotransferase Agxt.
- Subjects
AMINO acid metabolism; TYPE 2 diabetes; GLUCONEOGENESIS; LEAN body mass; HYPERGLYCEMIA; LIVER; BLOOD sugar
- Publication
Nature Communications, 2020, Vol 11, Issue 1, pN.PAG
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-020-19490-6