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- Title
Case report: Successful anterior temporal lobectomy in drug-resistant temporal lobe epilepsy associated with Sotos syndrome.
- Authors
Favi Bocca, Leonardo; Pereira Rodrigues, Thiago; Bortholin, Thiago; Targas Yacubian, Elza Márcia; Carrete Júnior, Henrique; Guaranha, Mirian; Silva Centeno, Ricardo
- Abstract
The Sotos syndrome is an autosomal dominant disorder characterized by haploinsufficiency of NSD1 gene, with some individuals affected by epilepsy and, rarely, drug-resistant seizures. A 47-years-old female patient with Sotos syndrome was diagnosed with focal-onset seizures in left temporal lobe, left-side hippocampal atrophy, and neuropsychological testing with decreased performance in several cognitive domains. Patient was treated with left-side temporal lobe resection and developed complete awake seizure control in 3-years of follow-up, with marked improvement in quality-of-life. In selected, clinically concordant patients, resective surgeries may play a significant role in improving patient's quality of life and seizure control.
- Subjects
TEMPORAL lobe epilepsy; EPILEPSY; TEMPORAL lobectomy; SEIZURES (Medicine); TEMPORAL lobe; SYNDROMES
- Publication
Frontiers in Neurology, 2023, Vol 14, p1
- ISSN
1664-2295
- Publication type
Article
- DOI
10.3389/fneur.2023.1126327