We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Novel insights into the bioenergetics of mixed-acid fermentation: Can hydrogen and proton cycles combine to help maintain a proton motive force?
- Authors
Trchounian, Armen; Gary Sawers, R.
- Abstract
Escherichia coli possesses four [NiFe]-hydrogenases that catalyze the reversible redox reaction of 2H+ + 2e− ↔ H2. These enzymes together have the potential to form a hydrogen cycle across the membrane. Their activity, operational direction, and interaction with each other depend on the fermentation substrate and particularly pH. The enzymes producing H2 are likely able to translocate protons through the membrane. Moreover, the activity of some of these enzymes is dependent on the F0F1-ATPase, thus linking a proton cycle with the cycling of hydrogen. These two cycles are suggested to have a primary basic role in modulating the cell's energetics during mixed-acid fermentation, particularly in response to pH. Nevertheless, the mechanisms underlying the physical interactions between these enzyme complexes, as well as how this is controlled, are still not clearly understood. Here, we present a synopsis of the potential impact of proton-hydrogen cycling in fermentative bioenergetics. © 2013 IUBMB Life, 66(1):1-7, 2014
- Subjects
BIOENERGETICS; FERMENTATION; ESCHERICHIA coli; HYDROGENASE; PROTON-proton cycle; OXIDATION-reduction reaction
- Publication
IUBMB Life, 2014, Vol 66, Issue 1, p1
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1002/iub.1236