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- Title
Randomized controlled trial on the safety of intracameral cephalosporins in cataract surgery.
- Authors
Lam, Philip T. H.; Young, Alvin L.; Cheng, Lulu L.; Tam, Patrick M. K.; Lee, Vincent Y. W.
- Abstract
Objective: To compare the safety profiles of intracameral cephalosporins in cataract surgery. Patients and methods: In this controlled trial, 129 patients were randomized to one of four groups to receive 1 mg of one of three cephalosporins - cefazolin, cefuroxime, or ceftazidime, or normal saline - given intracamerally during cataract surgery. Central endothelial cell density (ECD) and retinal center point thickness (CPT) were determined by specular microscopy and ocular coherence tomography, respectively, before and at 3 months after surgery. Results: There were no statistical significant differences in the changes of ECD and CPT between eyes receiving intracameral cephalosporin and control. Conclusion: The use of intracameral cefazolin, cefuroxime, or ceftazidime (1 mg in 0.1-mL solution) at the time of cataract surgery had no significant effect on ECD and CPT postoperatively.
- Publication
Clinical Ophthalmology, 2010, Vol 4, p1499
- ISSN
1177-5467
- Publication type
Article
- DOI
10.2147/OPTH.S15602