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- Title
The Cancer Stem Cell Marker CD133 Interacts with Plakoglobin and Controls Desmoglein-2 Protein Levels.
- Authors
Koyama-Nasu, Ryo; Takahashi, Rina; Yanagida, Satoshi; Nasu-Nishimura, Yukiko; Oyama, Masaaki; Kozuka-Hata, Hiroko; Haruta, Ryo; Manabe, Emi; Hoshino-Okubo, Akemi; Omi, Hiroko; Yanaihara, Nozomu; Okamoto, Aikou; Tanaka, Tadao; Akiyama, Tetsu
- Abstract
The pentaspan membrane glycoprotein CD133 (also known as prominin-1) has been widely used as a marker for both cancer and normal stem cells. However, the function of CD133 has not been elucidated. Here we describe a cancer stem cell line established from clear cell carcinoma of the ovary (CCC) and show that CD133 interacts with plakoglobin (also known as γ-catenin), a desmosomal linker protein. We further demonstrate that knockdown of CD133 by RNA interference (RNAi) results in the downregulation of desmoglein-2, a desmosomal cadherin, and abrogates cell-cell adhesion and tumorigenicity of CCC stem cells. We speculate that CD133 may be a promising target for cancer chemotherapy.
- Subjects
MEMBRANE glycoproteins; PROMININ; CANCER cells; STEM cells; RNA interference; CANCER chemotherapy
- Publication
PLoS ONE, 2013, Vol 8, Issue 1, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0053710