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- Title
The course of acute pancreatitis in children and potential simple laboratory markers of severity –A single Centre retrospective study.
- Authors
Kwiatek-Średzińska, Kamila; Kiryłowska, Martyna; Uścinowicz, Mirosława; Daniluk, Urszula; Lebensztejn, Dariusz
- Abstract
Aim: To evaluate the usefulness of routinely measured biochemical and complete blood count parameters as potential markers of the severity of paediatric acute pancreatitis (AP). Methods: The retrospective study included children with AP hospitalised over a 3 years period. Demographic, clinical and laboratory data were collected. Results: In total, 55 patients were enrolled in the study. Mild AP was diagnosed in 45 children (82%), moderately severe in 7 (13%), and severe in 3 patients (5%). Together 10 children (18%) were categorised into a single severe group. Children with severe AP had higher white blood cell and platelet counts on admission as well as a C-reactive protein (CRP) concentration after 48 h. The CRP concentration after 48 h (cut-off: 127.2 mg/L) and the white blood cell count on admission (cut-off: 13.5x10³/μl) were found to be statistically significant markers in predicting the severity of the disease. The CRP concentration after 48 h was demonstrated as an independent predictor. Conclusion: Severe AP is observed in a quite significant percentage of children. The white blood cell count on admission and the CRP concentration after 48 h (as an independent predictor) may be potential simple laboratory markers of the severity of the disease.
- Subjects
BIOMARKERS; LEUKOCYTE count; BLOOD cell count; PANCREATITIS; C-reactive protein
- Publication
Acta Paediatrica, 2022, Vol 111, Issue 11, p2229
- ISSN
0803-5253
- Publication type
Article
- DOI
10.1111/apa.16514