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- Title
Clinical Phenotype of Endothelial Dysfunction in a Lot of Romanian Scleroderma Patients.
- Authors
GROSEANU, Laura; BERGHEA, Florian; BALANESCU, Andra; PREDETEANU, Denisa; BOJINCA, Violeta; SAULESCU, Ioana; CONSTANTINESCU, Cosmin; OPRIS, Daniela; ABOBULUI, Mihai; BORANGIU, Andreea; NEGRU, Maria-Magdalena; VLAD, Violeta; IONESCU, Ruxandra
- Abstract
Objective: to identify the particularities of the clinical phenotype of endothelial dysfunction in a lot of Romanian patients from a reference center and compare it to data reported by international registries. Material and methods: 51 patients were included in a cross sectional study. The patients were evaluated for the pattern of disease, main visceral involvement, serum markers of disease. Results: 41.2% patients had history of digital ulcers, 27.45% had pulmonary arterial hypertension; cardiovascular involvement also included: diastolic dysfunction in 31.1% of the patients, global systolic dysfunction in 9.8%, rhythm and conduction disturbances in 19.6%, peripheral vascular disease in 19.6%. Scleroderma renal crisis was identified in 2 patients. Conclusions: Vascular complications are a major cause of morbidity and mortality in systemic sclerosis. Earlier therapeutic intervention demands improved screening and diagnosis in all cases.
- Subjects
ROMANIA; PHENOTYPES; ENDOTHELIUM diseases; SCLERODERMA (Disease); DIAGNOSIS; PATIENTS
- Publication
Maedica - a Journal of Clinical Medicine, 2015, Vol 10, Issue 4, p336
- ISSN
1841-9038
- Publication type
Article