We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Different Hydrogen-Bonded Interactions in the Cocrystals of Nicotinamide with Two Aromatic Acids.
- Authors
Lou, Benyong; Hu, Shuling
- Abstract
Nicotinamide crystallizes with 3-hydroxy-2-naphthoic acid and 4-aminobenzoic acid to give rise to cocrystal 1 and 2, respectively. Cocrystal 1, [CHO][CHNO], crystallizes in the monoclinic space group C2/c with a = 25.810(4), b = 4.8932(5), c = 23.869(4) Å, β = 107.078(8)º, V = 2881.6(7) Å, Z = 8, CHNO, M = 310.30, D = 1.431 g/cm. Cocrystal 2, [CHNO][CHNO]·HO, crystallizes in the triclinic space group P-1 with a = 7.214(5), b = 7.326(5), c = 13.484(11) Å, α = 83.23(2), β = 77.189(18), γ = 80.35(2)º, V = 682.7(9) Å, Z = 2, CHNO, M = 277.28, D = 1.349 g/cm. Similar carboxylic acid···pyridine synthon R(7) can be observed in the two cocrystals. In 1, amide of nicotinamide forms a C(4) chain from the anti H to its carbonyl oxygen. In 2, the amide forms a R(8) homodimer which is linked into 2D layer by water molecule through different hydrogen-bonding interactions. The 3D hydrogen-bonded structure results from a synthon R(8) from amide, water and amino group of 4-aminobenzoic acid. Graphical Abstract: Nicotinamide crystallizes with 3-hydroxy-2-naphthoic acid and 4-aminobenzoic acid to give rise to cocrystal 1 and 2, respectively. Similar carboxylic acid···pyridine synthon R(7) can be observed in the two cocrystals. In 1, amide of nicotinamide forms a C(4) chain from the anti H to its carbonyl oxygen. The syn H is accepted by hydroxyl oxygen of 3-hydroxy-2-naphthoic acid to form an infinite C(12) chain. In 2, the amide forms a R(8) homodimer which is linked into 2D layer by water molecule through different hydrogen-bonding interactions. The 3D hydrogen-bonded structure results from a synthon R(8) from amide, water and amino group of 4-aminobenzoic acid.[Figure not available: see fulltext.]
- Subjects
AMINO acids; OXYGEN; HYDROGEN bonding; MOLECULAR association; AMIDES
- Publication
Journal of Chemical Crystallography, 2011, Vol 41, Issue 11, p1663
- ISSN
1074-1542
- Publication type
Article
- DOI
10.1007/s10870-011-0154-z