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- Title
Glial fibrillary acidic protein (gfap) and anti-gfap autoantibody in canine necrotising meningoencephalitis.
- Authors
Toda, Y.; Matsuki, N.; Shibuya, M.; Fujioka, I.; Tamahara, S.; Ono, K.
- Abstract
To establish clinical markers for canine necrotising meningoencephalitis () and to elucidate its pathogenesis, glial fibrillary acidic protein () and anti- autoantibodies were measured in the cerebrospinal fluid () of 32 dogs with , 23 dogs with other inflammatory central nervous system () diseases, 27 dogs with miscellaneous diseases and 25 healthy dogs, including five pugs. The dogs with had the highest levels of anti- autoantibodies. The diagnostic sensitivity and specificity of anti- autoantibodies for were 91 per cent and 73 per cent, respectively. Some of the dogs with and the healthy pugs, had high concentrations of , suggesting a breed-specific fragility of astrocytes. The leakage of and the development of autoimmunity may be key to understanding the pathogenesis of .
- Publication
Veterinary Record: Journal of the British Veterinary Association, 2007, Vol 161, Issue 8, p261
- ISSN
0042-4900
- Publication type
Article
- DOI
10.1136/vr.161.8.261