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- Title
Host Defenses against Disseminated Candidiasis Are Impaired in Intercellular Adhesion Molecule 1-Deficient Mice.
- Authors
Davis, Susan L.; Hawkins, Edith P.; Mason, Edward O.; Smith, C. Wayne; Kaplan, Sheldon L.
- Abstract
Genetically engineered mice, which lack normal expression of intercellular adhesion molecule 1 (ICAM-1), were used to study the role ofICAM-1 in the host defense against disseminated candidiasis. The responses of ICAM-1-deficient mice and normal wild type mice were compared following an intravenous challenge with Candida albicans. ICAM-1-deficient mice lost more weight (P < .001) and had a significantly higher mortality (P < .001). Quantitative cultures revealed a greater tissue fungal burden in ICAM-1-deficient mice compared with normal mice, in both the kidney (P < .001)and the brain (P = .007). Extensive inflammation, composed primarily of histiocytes admixed with lymphocytes and occasional neutrophils, was present in the renal tissue of ICAM-1-deficient mice; this contrasted with a more localized and predominantly neutrophilic infiltrate in normal mice. This work suggests that the loss of ICAM-1 significantly impairs host defense against C. albicans, by impairing either neutrophil migration or phagocyte activation or both.
- Publication
Journal of Infectious Diseases, 1996, Vol 174, Issue 2, p435
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/174.2.435