We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Early Termination of a Prospective, Randomized Trial Comparing Teicoplanin and Flucloxacillin for Treating Severe Staphylococcal Infections.
- Authors
Calain, Philippe; Krause, Karl-Heinz; Vaudaux, Pierre; Auckenthaler, Raymond; Lew, Daniel; Waldvogel, Francis; Hirschel, Bernard
- Abstract
In a prospective, randomized trial, teicoplanin (at a 400-mg intravenous loading dose followed by 200 mg/day intravenously or intramuscularly) was compared with flucloxacillin (8 g/day) in patients with severe staphylococcal infections. Teicoplanin proved unsatisfactory for the following reasons: (1) failures or relapses were more frequent in the teicoplanin group, and (2) blood levels were difficult to predict and tended to be low 24 hr after the loading dose. Future trials with this agent should use much-higher doses.
- Publication
Journal of Infectious Diseases, 1987, Vol 155, Issue 2, p187
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/155.2.187