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- Title
Can chronic myeloid leukaemia in children and adolescents be successfully treated without haematopoietic stem cell transplant? A single centre experience.
- Authors
Giona, Fiorina; Moleti, Maria L.; De Benedittis, Daniela; Santopietro, Michelina; Nanni, Mauro; Testi, Anna M.; Orlando, Sonia; Iori, Anna P.; Piciocchi, Alfonso; Gottardi, Enrico; Barberi, Walter; Diverio, Daniela; Saglio, Giuseppe; Foà, Robin
- Abstract
We analysed the long-term outcome of 35 children and adolescents (<20 years at diagnosis) with chronic myeloid leukaemia ( CML) in chronic phase: 20 patients had received interferon-alpha and/or tyrosine kinase inhibitors ( TKIs), and 15 underwent a haematopoietic stem cell transplant. The 10-year survival probabilities were similar in transplanted and non-transplanted patients (73·3% vs. 72·1%, respectively), whereas the survival probability was significantly lower in patients diagnosed before 1999 compared to those diagnosed afterwards (62·1% vs. 100%, P = 0·0384). The availability of TKIs and the standardized molecular monitoring have significantly improved treatment, management and outcome in children and adolescents with CML.
- Subjects
MYELOID leukemia; STEM cell transplantation research; LEUKEMIA in children; CHRONIC diseases; INTERFERON alpha
- Publication
British Journal of Haematology, 2016, Vol 173, Issue 5, p749
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.13991