We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Validation of the revised international prognostic scoring system ( IPSS-R) in patients with lower-risk myelodysplastic syndromes: a report from the prospective European LeukaemiaNet MDS ( EUMDS) registry.
- Authors
Swart, Louise; Smith, Alex; Johnston, Thomas W.; Haase, Detlef; Droste, Jackie; Fenaux, Pierre; Symeonidis, Argiris; Sanz, Guillermo; Hellström‐Lindberg, Eva; Cermák, Jaroslav; Germing, Ulrich; Stauder, Reinhard; Georgescu, Otilia; MacKenzie, Marius; Malcovati, Luca; Holm, Mette S.; Almeida, Antonio M.; Mądry, Krzysztof; Slama, Borhane; Guerci‐Bresler, Agnes
- Abstract
Baseline characteristics, disease-management and outcome of 1000 lower-risk myelodysplastic syndrome ( MDS) patients within the European LeukaemiaNet MDS ( EUMDS) Registry are described in conjunction with the validation of the revised International Prognostic Scoring System ( IPSS-R). The EUMDS registry confirmed established prognostic factors, such as age, gender and World Health Organization 2001 classification. Low quality of life ( EQ-5D visual analogue scale score) was significantly associated with reduced survival. A high co-morbidity index predicted poor outcome in univariate analyses. The IPSS-R identified a large group of 247 patients with Low (43%) and Very low (23%) risk score within the IPSS intermediate-1 patients. The IPSS-R also identified 32 High or Very high risk patients within the IPSS intermediate-1 patients. IPSS-R was superior to the IPSS for predicting both disease progression and survival. Seventy percent of patients received MDS-specific treatment or supportive care, including red blood cell transfusions (51%), haematopoietic growth factors (58%) and iron chelation therapy (8%), within 2 years of diagnosis; while 30% of the patients only required active monitoring. The IPSS-R proved its utility as a more refined risk stratification tool for the identification of patients with a very good or poor prognosis and in this lower-risk MDS population.
- Subjects
HEALTH outcome assessment; MEDICAL registries; MYELODYSPLASTIC syndromes; QUALITY of life; PATIENTS; PROGNOSIS; DISEASE risk factors
- Publication
British Journal of Haematology, 2015, Vol 170, Issue 3, p372
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.13450