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- Title
Body composition and fat repartition in relation to structure and function of large arteries in middle-aged adults (the SU.VI.MAX study).
- Authors
Czernichow, S; Bertrais, S; Oppert, J-M; Galan, P; Blacher, J; Ducimetière, P; Hercberg, S; Zureik, M; Ducimetière, P
- Abstract
<bold>Objective: </bold>To investigate associations of body composition assessed by bioimpedance analysis and anthropometric indicators of fat repartition with carotid structure and function. <bold>Design: </bold>Cross-sectional epidemiological study. <bold>Subjects: </bold>A total of 1014 middle-aged apparently healthy adults participating in the SU.VI.MAX study. <bold>Measurements: </bold>Body composition (fat mass, fat-free mass) was assessed by bioimpedance analysis and anthropometric indicators of fat repartition (waist circumference (WC); waist-hip-ratio (WHR)) were simultaneously collected. Carotid ultrasound examination included measurements of intima-media thickness (IMT) at the common carotid arteries (CCA) and assessment of atherosclerotic plaques in extracranial carotid arteries. Carotid-femoral pulse-wave velocity (PWV) was used as a marker of aortic stiffness. <bold>Results: </bold>In multivariate analyses adjusted for major known cardiovascular risk factors in addition to age, gender and height, fat-free mass, fat mass (FM), and WC were positively associated with CCA-IMT and lumen diameter. No significant association was found with occurrence of carotid plaques. PWV was only associated with WC. Associations of CCA-IMT and PWV with WC were not significant anymore after further adjustment on body mass index (BMI) or FM. <bold>Conclusion: </bold>WC was the only measurement positively associated with both early atherosclerosis markers such as CCA-IMT and arterial stiffness. Although this association depends on overall adiposity, as assessed by the BMI, it emphasizes the importance of WC in clinical practice and prevention programs as a screening tool for individuals at risk for cardiovascular disease.
- Subjects
HUMAN body composition; MIDDLE-aged persons; ARTERIES; FAT; ADIPOSE tissues; ANATOMY
- Publication
International Journal of Obesity, 2005, Vol 29, Issue 7, p826
- ISSN
0307-0565
- Publication type
journal article
- DOI
10.1038/sj.ijo.0802986