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- Title
Reliable screening for acute pancreatitis with rapid urine trypsinogen-2 test strip.
- Authors
Kylänpää-Bäck, M. -L.; Kemppainen, E.; Puolakkainen, P.; Hedström, J.; Haapiainen, R.; Perhoniemi, V.; Kivilaakso, E.; Korvuo, A.; Stenman, U. -H.
- Abstract
Summary Background: This study was designed to evaluate the validity of a new rapid urinary trypsinogen-2 test strip (Actim Pancreatitis) for detection of acute pancreatitis in patients with acute abdominal pain. Methods: A total of 525 consecutive patients presenting with abdominal pain at two emergency units was included prospectively and tested with the Actim Pancreatitis test strip. Urine trypsinogen-2 concentrations were also determined by a quantitative method. The diagnosis and assessment of severity of acute pancreatitis was based on raised serum and urinary amylase levels, clinical features and findings on dynamic contrast-enhanced computed tomography. Results: In 45 patients the diagnosis of acute pancreatitis could be established. The Actim Pancreatitis test strip result was positive in 43 of them resulting in a sensitivity of 96 per cent. Thirty-seven false-positive Actim Pancreatitis test strips were obtained in patients with non-pancreatic abdominal pain resulting in a specificity of 92 per cent. Nine patients with severe acute pancreatitis were all detected by the dipstick. Conclusion: A negative Actim Pancreatitis strip result excludes acute pancreatitis with high probability. Positive results indicate the need for further evaluation, i.e. other enzyme measurements and/or radiological examinations. The test is easy and rapid to perform, unequivocal in its interpretation and can be used in healthcare units lacking laboratory facilities.
- Subjects
PANCREATITIS diagnosis; ABDOMINAL pain; TRYPSINOGEN
- Publication
British Journal of Surgery, 2000, Vol 87, Issue 1, p49
- ISSN
0007-1323
- Publication type
Article
- DOI
10.1046/j.1365-2168.2000.01298.x