We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Anti- and Proinflammatory Effects of 15-Deoxy-Δ<sup>12,14</sup>-Prostaglandin J<sub>2</sub>(15d-PGJ<sub>2</sub>) on Human Eosinophil Functions.
- Authors
Ueki, Shigeharu; Kato, Hikari; Kobayashi, Yoshiki; Ito, Wataru; Adachi, Tetsuya; Nagase, Hiroyuki; Ohta, Ken; Kayaba, Hiroyuki; Chihara, Junichi
- Abstract
The cyclopentenone prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is recognized as a potent lipid mediator that is derived from PGD2, which is produced abundantly in allergic inflammatory sites. It is now established that 15d-PGJ2 negatively regulates cellular functions through its intracellular targets such as peroxisome proliferator-activated receptor-γ (PPARγ). However, recent studies revealed that 15d-PGJ2 appears to possess not only anti-inflammatory activities but also a proinflammatory potential depending on its concentration and the activation state of the target cell. For instance, at low concentrations, 15d-PGJ2 enhances eotaxin-induced chemotaxis, shape change, and actin reorganization in eosinophils through its ligation with PPARγ. Moreover, 15d-PGJ2 itself is a potent chemoattractant, and it induces calcium mobilization, and up-regulates CD11b expression through its membrane receptor – chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). Conversely, at high concentrations, 15d-PGJ2 inhibits eosinophil survival by inducing apoptosis in a PPARγ-independent manner. Here, we discuss the pathophysiological roles of 15d-PGJ2 that could act as a paracrine, autocrine, and intracrine substance to regulate eosinophil functions. Copyright © 2007 S. Karger AG, Basel
- Subjects
PROSTAGLANDINS; BIOCHEMISTRY; LEUCOCYTES; T cells; APOPTOSIS; CELL death
- Publication
International Archives of Allergy & Immunology, 2007, Vol 143, p15
- ISSN
1018-2438
- Publication type
Article
- DOI
10.1159/000101399