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- Title
Effects of Sex Steroid Analogs on Spontaneous Autoimmune Thyroiditis in Obese Strain Chickens.
- Authors
Schuurs, A.H.W.M.; Dietrich, H.; Gruber, J.; Wick, G.
- Abstract
Treatment of obese strain chickens, either in ovo or after hatching, with testosterone or various testosterone-derived steroid analogs having no or only weak endocrine activities causes significant protection from spontaneous autoimmune thyroiditis occurring in these birds. This effect is not correlated with the endocrinological properties of these steroids. This observation and similar results in other models for autoimmunity may present a basis for a more selective therapy in human autoimmune diseases in that hormonal side effects no longer preclude this approach. Copyright © 1992 S. Karger AG, Basel
- Publication
International Archives of Allergy & Immunology, 1992, Vol 97, Issue 4, p337
- ISSN
1018-2438
- Publication type
Article
- DOI
10.1159/000236142