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- Title
Italian addison network study: update of diagnostic criteria for the etiological classification of primary adrenal insufficiency.
- Authors
Falorni, Alberto; Laureti, Stefano; De Bellis, Annamaria; Zanchetta, Renato; Tiberti, Claudio; Arnaldi, Giorgio; Bini, Vittorio; Beck-Peccoz, Paolo; Bizzarro, Antonio; Dotta, Francesco; Mantero, Franco; Bellastella, Antonio; Betterle, Corrado; Santeusanio, Fausto; SIE Addison Study Group
- Abstract
Primary adrenal insufficiency (PAI) is clinically evident in one in 8000 individuals. A correct etiological classification is critical for correct disease management. To update the diagnostic criteria for the etiological classification of PAI, a multicentric network was established in Italy, and 222 patients with PAI were studied. Both 21-hydroxylase and adrenal cortex autoantibodies (21OHAb and ACA, respectively) were tested in two independent laboratories on coded samples and found in 65-66% and 58-61% of cases, respectively. Autoimmune polyendocrine syndrome I was diagnosed in 11 of the 222 patients. Of the remaining 211 patients, 38 (18%) had a nonautoimmune form of PAI. In 145 subjects (65%), the presence of adrenal autoantibodies, without signs of other forms of PAI, led to a diagnosis of autoimmune Addison's disease. In six cases (3%), PAI remained idiopathic. Logistic regression analysis showed a 92.2-92.7% probability of correct reclassification for the two 21OHAb assays and 84.5-85.9% for the ACA assays. We conclude that the simultaneous presence of both 21OHAb and ACA permits unambiguous diagnosis of autoimmune Addison's, whereas subjects with low antibody titers should undergo both instrumental and biochemical tests to exclude other causes of PAI. Lastly, we developed a comprehensive flowchart for the classification of PAI for use in routine clinical practice.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2004, Vol 89, Issue 4, p1598
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2003-030954