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- Title
Intravitreal moxifloxacin injections in acute post-cataract surgery endophthalmitis: Efficacy and safety.
- Authors
Agarwal, Abhishek; Nagpal, Manisha
- Abstract
<bold>Purpose: </bold>The aim of this study was to evaluate the efficacy and safety of intravitreal moxifloxacin injections in the treatment of acute post-cataract surgery endophthalmitis with visual acuity equal to or greater than hand movements.<bold>Methods: </bold>Fifty two patients with post-cataract surgery endophthalmitis who presented within 6 weeks with visual acuity equal to or greater than hand movements received two intravitreal moxifloxacin injections 48 h apart. Patients with prior history of ocular disease or treatment were excluded. Patients were followed up to 3 months either for resolution of endophthalmitis or worsening of disease. Number of patients who achieved visual acuity equal to or better than 20/40 and 20/200 at the third-month follow-up visit were compared with the number of patients at presentation, using Chi-square test. In addition, pretreatment LogMAR visual acuity at the time of presentation was compared with posttreatment visual acuity at end of third month using paired t test.<bold>Results: </bold>Fifty (96.15%) patients showed complete resolution of endophthalmitis while three patients required vitrectomy. Forty-one (78.85%) and 49 (94.23%) patients achieved visual acuity equal to or better than 20/40 and 20/200, respectively, at the third-month follow-up visit as compared to eight (15.38%) and 13 (25%) patients, respectively, at presentation (P < 0.05). In addition, mean LogMAR visual acuity at the time of presentation was 0.755 which improved to 0.307 at the third-month follow-up visit (P < 0.05). None of the patients developed hypersensitivity reactions to intravitreal moxifloxacin.<bold>Conclusion: </bold>Intravitreal moxifloxacin injections showed promising results in acute post-cataract surgery endophthalmitis.
- Subjects
VISUAL acuity; MOXIFLOXACIN; INJECTIONS; THERAPEUTICS; CHI-squared test; PHACOEMULSIFICATION; DIAGNOSIS of bacterial diseases; ANTIBIOTICS; CATARACT; RETROSPECTIVE studies; CATARACT surgery; EYE infections; ENDOPHTHALMITIS; BACTERIAL diseases
- Publication
Indian Journal of Ophthalmology, 2021, Vol 69, Issue 2, p326
- ISSN
0301-4738
- Publication type
journal article
- DOI
10.4103/ijo.IJO_587_20