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- Title
Risk Factors for Postoperative Recurrence in Korean Patients with Crohn's Disease.
- Authors
Sung Bae Kim; Jae Hee Cheon; Jae Jun Park; Eun Soo Kim; Seong Woo Jeon; Sung-Ae Jung; Dong Il Park; Chang Kyun Lee; Jong Pil Im; You Sun Kim; Hyun Soo Kim; Jun Lee; Chang Soo Eun; Jeong Mi Lee; Byung Ik Jang; Geom Seog Seo
- Abstract
Background/Aims: A considerable number of patients with Crohn's disease still need intestinal resection surgery. Postoperative recurrence is an important issue in Crohn's disease management, including the selection of high-risk patients. Eastern Asian patients showed several differences from Caucasian patients. Therefore, we investigated the postoperative surgical recurrence outcome and identified risk factors in Korean patients. Methods: Clinical data of 372 patients with Crohn's disease who underwent first intestinal resection between January 2004 and August 2014 at 14 hospitals in Korea were retrospectively reviewed. Results: Over the follow-up period, 50 patients (17.1%) showed surgical recurrence. The cumulative surgical recurrence rate was 6.5% at 1 year and 15.4% at 7 years. Age under 16 (p=0.011; hazard ratio [HR], 5.136; 95% confidence interval [CI], 1.576 to 16.731), colonic involvement (p=0.023; HR , 2.011; 95% CI, 1.102 to 3.670), and the presence of perianal disease at surgery (p=0.008; HR, 2.239; 95% CI, 1.236 to 4.059) were independent risk factors associated with surgical recurrence. Postoperative thiopurine treatment (p=0.002; HR, 0.393; 95% CI, 0.218 to 0.710) was a protective factor for surgical recurrence. Conclusions: Among the disease characteristics at surgery, younger age, colonic location, and perianal lesions were independent risk factors for surgical recurrence. Postoperative thiopurine treatment significantly reduced the incidence of surgical recurrence.
- Subjects
SOUTH Korea; CROHN'S disease; JUVENILE idiopathic arthritis; SURGICAL excision; INTESTINAL surgery; INTESTINE transplantation
- Publication
Gut & Liver, 2020, Vol 14, Issue 3, p331
- ISSN
1976-2283
- Publication type
Article
- DOI
10.5009/gnl19085