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- Title
Prevalence of transmitted drug resistance mutations among newly diagnosed HIV‐1‐infected patients in a large teaching hospital of the Northern Italy.
- Authors
Calza, Leonardo; Tamburello, Martina; Borderi, Marco; Colangeli, Vincenzo; Testi, Diletta; Amedeo, Alberto; Re, Maria Carla; Bon, Isabella
- Abstract
The surveillance DRMs were associated with the main classes of antiretroviral agents: nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), and integrase strand transfer inhibitors (INSTIs). DRMs were also more frequent among patients infected with B subtype (10 of 101 patients; 9.9%) compared with those infected with non-B subtypes (4 of 77 patients; 5.2%). In this study, prevalence of non-B subtypes was significant (33%), and a major INSTI mutation (Q148H) was detected in two naïve patients.10 In our study, the prevalence of TDR in newly diagnosed HIV-1-infected patients was comparable or lower than that observed in other Italian or European cohort studies.
- Subjects
NORTHERN Italy; DRUG resistance; TEACHING hospitals; NON-nucleoside reverse transcriptase inhibitors
- Publication
Journal of Medical Virology, 2020, Vol 92, Issue 8, p929
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.25896