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- Title
Radiosynthesis and validation of [5-cyano-N-(4-(4-[<sup>11</sup>C] methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl) furan-2- carboxamide] ([<sup>11</sup>C]CPPC), a PET radiotracer for imaging CSF1R, a microglia-specific marker.
- Authors
Mathews, William B.; Yunkou Wu; Horti, Andrew G.; Naik, Ravi; Hall, Andrew W.; Holt, Daniel P.; Dannals, Robert F.
- Abstract
In this practitioner protocol, the radiochemical synthesis of [11C]CPPC is described in detail, and a quality control summary of three validation productions is presented. The results indicate that the radiotracer product can be produced in good radiochemical yield (> 60 mCi (2.22 GBq) at end-ofsynthesis (EOS)), at high specific activity (molar activity > 11,435 mCi/µmole (423 GBq/μmole) at EOS) and high chemical and radiochemical purity. The entire production conforms to current Good Manufacturing Practice (cGMP) requirements. The final product is formulated as a sterile, pyrogen-free solution suitable for human injection.
- Subjects
RADIOACTIVE tracers; CURRENT good manufacturing practices; RADIOCHEMICAL purification
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2019, Vol 62, Issue 13, p903
- ISSN
0362-4803
- Publication type
Article
- DOI
10.1002/jlcr.3806