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- Title
Sacral neuromodulation for overactive bladder in women: do age and comorbidities make a difference?
- Authors
High, Rachel A.; Winkelman, William; Panza, Joseph; Sanderson, Derrick J.; Yuen, Hyde; Halder, Gabriela; Shaver, Courtney; Bird, Erin T.; Rogers, Rebecca G.; Danford, Jill M.
- Abstract
Objective: To evaluate if age and comorbidities are associated with progression from trial phase to implantation of an implantable pulse generator in women with overactive bladder. Methods: This multisite retrospective cohort included women with overactive bladder with or without urinary incontinence who had a trial phase for sacral neuromodulation. The primary outcome was progression to implantation. A sub-analysis of implanted patients was performed for the outcome of additional therapies or "implant only" for the duration of follow-up. Multivariate logistic regression models including potential predictors of implantation and post-implantation addition of therapies were performed. Results: At six academic institutions, 91% (785/864) of patients progressed to implantation. Post-implantation success was achieved by 69% (536/782) of patients at median follow-up of 2 (range 0.3 to 15) years. Odds of implantation [OR 0.73 (CI 0.61, 0.88)] and post-implantation success [OR 0.78 (CI 0.98, 0.97)] were lower with increasing decades of age. Medical comorbidities evaluated did not affect implantation rates or post-implant success. Conclusions: Most women have successful sacral neuromodulation trials despite older age and comorbidities. Higher decade of age has a negative effect on odds of implantation and is associated with addition of therapies post-implantation. Comorbidities assessed in this study did not affect implantation or addition of therapies post-implantation. Most women add therapies to improve efficacy post-implantation, and explantation rates are low.
- Subjects
OVERACTIVE bladder; COMORBIDITY; PULSE generators; CYSTOMETRY; URINARY incontinence; LOGISTIC regression analysis
- Publication
International Urogynecology Journal, 2021, Vol 32, Issue 1, p149
- ISSN
0937-3462
- Publication type
Article
- DOI
10.1007/s00192-020-04392-4