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- Title
Isolation and Characterization of a New Flavonoid Glucoside from Aerial Parts of Phrynium placentarium.
- Authors
De, U.; Bhowmik, J.; Chowdhury, S.; Basak, A.; Dinda, B.
- Abstract
A new flavonoid glucoside ( 1) has been isolated from the aerial parts of Phrynium placentarium (Marantaceae). The structure of 1 was established as 5,2′-dihydroxy-3′,4′-dimethoxyflavone-7-O- β-D-glucopyranoside by means of chemical and spectral data including 2D NMR studies. Compound 1 was examined for antioxidant and PCSK3 (furin) inhibition efficacy because inhibitors of furin are under consideration as therapeutic agents for treating various diseases, including HIV, influenza, dengue fever, etc. Experimental results showed antioxidant activity with EC value of 100 μg/mL and PCSK3 inhibition activity with EC value of 80 μg/mL on spectrophometric assays.
- Subjects
FLAVONOIDS; FLAVONOID glycosides; THAUMATOCOCCUS daniellii; INFLUENZA; HIV
- Publication
Chemistry of Natural Compounds, 2015, Vol 51, Issue 3, p444
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-015-1311-y