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- Title
The role of FLT3 in haematopoietic malignancies.
- Authors
Stirewalt, Derek L.; Radich, Jerald P.
- Abstract
Normal haematopoietic cells use complex systems to control proliferation, differentiation and cell death. The control of proliferation is, in part, accomplished through the ligand-induced stimulation of receptor tyrosine kinases, which signal to downstream effectors through the RAS pathway. Recently, mutations in the FMS-like tyrosine kinase 3 (FLT3) gene, which encodes a receptor tyrosine kinase, have been found to be the most common genetic lesion in acute myeloid leukaemia (AML), occurring in ~25% of cases. Exploring the mechanism by which these FLT3 mutations cause uncontrolled proliferation might lead to a better understanding of how cells become cancerous and provide insights for the development of new drugs.
- Subjects
CANCER; CELL proliferation; CELL death; PROTEIN-tyrosine kinases; GENETIC mutation
- Publication
Nature Reviews Cancer, 2003, Vol 3, Issue 9, p650
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc1169