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- Title
Inflammation-induced interstitial migration of effector CD4<sup>+</sup> T cells is dependent on integrin α<sub>V</sub>.
- Authors
Overstreet, Michael G; Gaylo, Alison; Angermann, Bastian R; Hughson, Angela; Hyun, Young-Min; Lambert, Kris; Acharya, Mridu; Billroth-MacLurg, Alison C; Rosenberg, Alexander F; Topham, David J; Yagita, Hideo; Kim, Minsoo; Lacy-Hulbert, Adam; Meier-Schellersheim, Martin; Fowell, Deborah J
- Abstract
Leukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues seems to be integrin independent and based on actomyosin-mediated protrusion and contraction, during inflammation, changes to the extracellular matrix (ECM) may necessitate distinct motility requirements. Indeed, we found that the interstitial motility of T cells was critically dependent on Arg-Gly-Asp (RGD)-binding integrins in the inflamed dermis. Inflammation-induced deposition of fibronectin was functionally linked to higher expression of integrin αV on effector CD4+ T cells. By intravital multiphoton imaging, we found that the motility of CD4+ T cells was dependent on αV expression. Selective blockade or knockdown of αV arrested T helper type 1 (TH1) cells in the inflamed tissue and attenuated local effector function. Our data demonstrate context-dependent specificity of lymphocyte movement in inflamed tissues that is essential for protective immunity.
- Subjects
INFLAMMATION; T cells; ACTOMYOSIN; CD4 antigen; INTEGRINS; INTERSTITIAL cells; CELL migration
- Publication
Nature Immunology, 2013, Vol 14, Issue 9, p949
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.2682