We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The network of P-glycoprotein and microRNAs interactions.
- Authors
Lopes‐Rodrigues, Vanessa; Seca, Hugo; Sousa, Diana; Sousa, Emília; Lima, Raquel T.; Vasconcelos, M. Helena
- Abstract
Overexpression of P-glycoprotein (P-gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P-gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to date. Apart from its role in drug efflux, P-gp may have other cellular functions such as being involved in apoptosis, and is found in various locations in the cell. Its expression is highly regulated, namely by microRNAs (miRNAs or miRs). In addition, P-gp may regulate the expression of miRs in the cell. Furthermore, both P-gp and miRs may be found in microvesicles or exosomes and may be transported to neighboring, drug-sensitive cells. Here, we review this current issue together with recent evidence of this network of interactions between P-gp and miRs.
- Publication
International Journal of Cancer, 2014, Vol 135, Issue 2, p253
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.28500