We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Caustic esophageal injury decreases the number of interstitial cells of Cajal in the rat esophagus.
- Authors
Soyer, Tutku; Ayva, Şebnem; Somuncu, Salih; Atasoy, Pınar; Kanmaz, Turan; Çakmak, Murat
- Abstract
Aim: To evaluate the effect of caustic esophageal injury (CEI) on the number of interstitial cells of Cajal (ICC). Materials and methods:Wistar rats were divided into 3 groups: control, acid, and alkali induced CEI. CEI was performed by the injection of 1 mL of 10% hypochloric acid in the acid group, and 1 mL of 10% sodium hydroxide was injected into the alkali group. Distal esophageal segments were removed 24 h after injection. CEI was graded and the number of ICC were investigated (CD-117 staining). The number of ICC was compared in groups and correlated with CEI grades. Results: Typical histopathologic features of CEI were encountered in acid (mean grade: 0.25 ± 0.15), and in alkali (median: 2, range: 1.25-3) groups. The number of ICC was decreased in both the acid (mean: 12.8 ± 9.2) and alkali (median: 2, range: 0.0-4.0) groups with respect to the control group (mean: 30.5 ± 6.5) (P < 0.05). In addition, alkali group had a decreased number of ICC, when compared to the acid group (P < 0.05). Histopathologic grading showed an inverse correlation with number of ICC in both the acid (rs: 0.678) and alkali (rs: 0.759) groups. Conclusion: CEI decreases the number of ICC in the rat esophagus. Alkali caustics cause a higher grade of esophageal injury and a greater decrease in the number of ICC. Motility disorders after caustic ingestion may be related to the decreased number of ICC.
- Subjects
ESOPHAGEAL injuries; INTERSTITIAL lung diseases; ESOPHAGEAL motility disorders; HISTOPATHOLOGY; SODIUM hydroxide; LABORATORY rats
- Publication
Turkish Journal of Medical Sciences, 2010, Vol 40, Issue 4, p599
- ISSN
1300-0144
- Publication type
Article
- DOI
10.3906/sag-0809-9