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- Title
BDNF-Deficient Mice Show Reduced Psychosis-Related Behaviors Following Chronic Methamphetamine.
- Authors
Manning, Elizabeth E.; Halberstadt, Adam L.; van den Buuse, Maarten
- Abstract
Background: One of the most devastating consequences of methamphetamine abuse is increased risk of psychosis. Brainderived neurotrophic factor has been implicated in both psychosis and neuronal responses to methamphetamine. We therefore examined persistent psychosis-like behavioral effects of methamphetamine in brain-derived neurotrophic factor heterozygous mice. Methods: Mice were chronically treated with methamphetamine from 6 to 9 weeks of age, and locomotor hyperactivity to an acute D-amphetamine challenge was tested in photocell cages after a 2-week withdrawal period. Results: Methamphetamine-treated wild-type mice, but not brain-derived neurotrophic factor heterozygous mice, showed locomotor sensitization to acute 3 mg/kg D-amphetamine. Qualitative analysis of exploration revealed tolerance to D-amphetamine effects on entropy in methamphetamine-treated brain-derived neurotrophic factor heterozygous mice, but not wild-type mice. Conclusions: Chronic methamphetamine exposure induces contrasting profiles of behavioral changes in wild-type and brainderived neurotrophic factor heterozygous mice, with attenuation of behaviors relevant to psychosis in methamphetaminetreated brain-derived neurotrophic factor heterozygous mice. This suggests that brain-derived neurotrophic factor signalling changes may contribute to development of psychosis in methamphetamine users.
- Subjects
METHAMPHETAMINE; LABORATORY mice; PSYCHOSES; NEUROTROPHIC functions; NEUROTROPHINS
- Publication
International Journal of Neuropsychopharmacology, 2016, Vol 19, Issue 4, p1
- ISSN
1461-1457
- Publication type
Article
- DOI
10.1093/ijnp/pyv116